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- Title
Successful treatment of hairy cell leukemia variant with rituximab.
- Authors
Narat, S; Gandla, J; Dogan, A; Mehta, A
- Abstract
Hairy cell leukemia (HCL) variant is a rare low-grade B-cell disorder affecting the elderly or middle-aged population with features intermediate between those of HCL and prolymphocytic leukemia. Unlike HCL, it is resistant to most conventional treatment. We report a case of a 53-year-old man who had refractory thrombocytopenia and lymphocytosis for 8 years. Investigations and analysis of spleen and bone marrow revealed a diagnosis of HCL variant. He opted for treatment with rituximab, a chimeric monoclonal antibody targeting CD 20. There was complete recovery of his full blood count and a bone marrow biopsy performed 3 months post-treatment showed complete remission. This is, to our knowledge, the first reported patient with HCL variant for whom treatment with rituximab was successful, and this treatment needs further investigation.
- Publication
Leukemia & lymphoma, 2005, Vol 46, Issue 8, p1229
- ISSN
1042-8194
- Publication type
Journal Article
- DOI
10.1080/10428190500083433