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- Title
Aggressive Natural Killer-Cell Leukemia: report of five cases and review of the literature.
- Authors
Ruskova, Anna; Thula, Rekha; Chan, George
- Abstract
We report 5 cases of Aggressive Natural Killer-Cell Leukemia (ANKL) diagnosed and treated in our institution within a period of 5 years. Presented are the clinical, hematological, immunophenotypic, immunogenotypic and cytogenetic data. ANKL is a very rare disorder. On review of the English-language literature only 68 published cases were identified. Analysis was performed on a total number of 73 cases (68 from the literature and the series of 5 presented hereby). Presented and discussed are the epidemiology, clinical picture, morphology, cell marker, immunogenotype, cytogenetics, and survival data of the analysis, as well as the associations with the Epstein-Barr virus (EBV). To our knowledge this is the largest series of cases of ANKL analyzed and therefore it is hoped to contribute towards a better characterization of the disorder.
- Publication
Leukemia & lymphoma, 2004, Vol 45, Issue 12, p2427
- ISSN
1042-8194
- Publication type
Journal Article
- DOI
10.1080/10428190400004513