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- Title
Characterization of AP3B2_v2, a novel splice variant of human AP3B2.
- Authors
Chen, Chunjing; Zou, Xianqiong; Ji, Chaoneng; Zhao, Shuo; Lv, Lei; Gu, Shaohua; Xie, Yi; Mao, Yumin
- Abstract
A novel splice variant of human AP3B2, named AP3B2_v2, was isolated through the large-scale sequencing analysis of a human fetal brain cDNA library. The AP3B2_v2 cDNA is 1171 bp in length. Sequence analysis revealed AP3B2_v2 missed 22 exons that existed in AP3B2_v1, leading to a different putative protein. The deduced proteins were 145 amino acids (designated as AP3B2_v2) and 1082 amino acids (AP3B2_v1) in length, sharing the C-terminal 145 amino acids. RT-PCR analysis showed that human AP3B2_v2 were expressed in several human adult tissues analyzed. The expression levels of AP3B2_v2 were relatively high in brain and testis. In contrast, low levels of expression were detected in kidney, pancreas, spleen, thymus, prostate, ovary and small intestine.
- Publication
DNA sequence : the journal of DNA sequencing and mapping, 2007, Vol 18, Issue 3, p165
- ISSN
1042-5179
- Publication type
Journal Article
- DOI
10.1080/10425170600842121