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- Title
Genomic organization of mouse desmocollin genes reveals evolutionary conservation.
- Authors
Kljuic, Ana; Bauer, Robert C; Christiano, Angela M
- Abstract
Desmosomal cadherins are a family of calcium regulated proteins involved in the formation of desmosomes, a type of cell junction important in maintaining cell adhesion and tissue stability. The desmosomal plaque consists of members of the desmosomal cadherin, plakin and armadillo family of proteins. Desmosomal cadherins are transmembrane glycoproteins that interact with desmosomal cadherins of the adjacent cells via their extracellular repeat domains and are divided in two subfamilies, the desmogleins (Dsg) and the desmocollins (Dsc). On the cytoplasmic side, the cadherins connect to the intermediate filament (IF) network indirectly by interacting with plakin and armadillo proteins. Here, we report the elucidation of the genomic structure of two mouse desmocollin genes, Dsc2 and Dsc3. Interestingly, at the genomic level, desmocollins show a higher degree of similarity to the classical cadherins, such as E-cadherin, than to the desmogleins.
- Publication
DNA sequence : the journal of DNA sequencing and mapping, 2004, Vol 15, Issue 2, p148
- ISSN
1042-5179
- Publication type
Journal Article
- DOI
10.1080/10425170410001679156