We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hormetic responses in neural systems: consideration, contexts, and caveats.
- Authors
Giordano, James; Ives, John A; Jonas, Wayne B
- Abstract
Dr. Edward Calabrese asserts that hormetic responses occur in neural systems, and provides ample review of evidence to support this claim. In this essay, we survey Dr. Calabrese's findings, illustrate the somewhat provocative premise of hormesis, and posit that while evidence suggests that amplification of low-dose effects are operative in neural systems, it is equally important to consider observations and claims of hormesis in greater detail, and framed within the "cultural" and epistemic contexts of science. We offer specific caveats to avoid the overgeneralization of findings, oversimplification of putative effects or mechanisms, and the dogmatic adherence to a restrictive methodologic orientation. Finally, we assert that any meaningful discussion of hormesis must be grounded to methodologic rigor, yet openness, and must allow for a self-critical and self-revisionist epistemic approach. We attempt to show that the work presented by Calabrese takes a first and important step toward the initiation of dialectic, allows for the exchange of ideas, strives toward reconciliation of differences and the amelioration of error, and seeks intellectual synthesis.
- Publication
Critical reviews in toxicology, 2008, Vol 38, Issue 7, p623
- ISSN
1547-6898
- Publication type
Journal Article
- DOI
10.1080/10408440802026356