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- Title
Streptococcus pneumoniae protein vaccine candidates: properties, activities and animal studies.
- Authors
Tai, Stanley S
- Abstract
Streptococcus pneumoniae is a causative agent for community acquired pneumonia, bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant clinical isolates prompts the need of effective vaccine for the prevention of disease. The licensed polysaccharide-based pneumococcal vaccines only elicit protective antibodies against the infection of serotypes that are included in the vaccine. To broaden the protection, the use of pneumococcal proteins will be a feasible and preferable alternative. This communication provides a review on the biochemical properties of these protein candidates, their immunization results in animal studies, and perspectives on the development of protein-based pneumococcal vaccine.
- Publication
Critical reviews in microbiology, 2006, Vol 32, Issue 3, p139
- ISSN
1040-841X
- Publication type
Journal Article
- DOI
10.1080/10408410600822942