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- Title
ER-to-Golgi transport: COP I and COP II function (Review).
- Authors
Duden, Rainer
- Abstract
COP I and COP II coat proteins direct protein and membrane trafficking in between early compartments of the secretory pathway in eukaryotic cells. These coat proteins perform the dual, essential tasks of selecting appropriate cargo proteins and deforming the lipid bilayer of appropriate donor membranes into buds and vesicles. COP II proteins are required for selective export of newly synthesized proteins from the endoplasmic reticulum (ER). COP I proteins mediate a retrograde transport pathway that selectively recycles proteins from the cis-Golgi complex to the ER. Additionally, COP I coat proteins have complex functions in intra-Golgi trafficking and in maintaining the normal structure of the mammalian interphase Golgi complex.
- Publication
Molecular membrane biology, 2003, Vol 20, Issue 3, p197
- ISSN
0968-7688
- Publication type
Journal Article
- DOI
10.1080/0968768031000122548