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- Title
Conversion of circulating estrone sulfate to 17beta-estradiol by ovarian tumor tissue: a possible mechanism behind elevated circulating concentrations of 17beta-estradiol in postmenopausal women with ovarian tumors.
- Authors
Kirilovas, Dmitrijus; Schedvins, Kjell; Naessén, Tord; Von Schoultz, Bo; Carlström, Kjell
- Abstract
Elevated serum levels of 17beta-estradiol (E2) are frequently found in postmenopausal women with ovarian tumors not classified as estrogen-producing. Conversion of circulating estrone sulfate (E1S) to E2 is one alternative way of E2 formation in target tissues in postmenopausal women. Our aim was to find out if conversion of circulating E1S to E2 by the tumor tissue could be a reason for elevated serum E2 levels in postmenopausal women with 'non-estrogen-producing' ovarian tumors.
- Publication
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2007, Vol 23, Issue 1, p25
- ISSN
0951-3590
- Publication type
Journal Article
- DOI
10.1080/09513590601058333