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- Title
Systemic mastocytosis with associated acute myelogenous leukemia.
- Authors
Zhrebker, Leah; Cooper, Barry; Krause, John R
- Abstract
Systemic mastocytosis (SM) is a condition associated with a clonal neoplastic proliferation of mast cells. Approximately 40% of patients with SM present with an associated clonal hematological non-mast cell lineage disorder. Patients presenting with SM-acute myeloid leukemia (AML) have the worst prognosis. We present a case of a 62-year-old woman who was diagnosed with SM-AML. After initial treatment with a standard regimen of cytosine arabinoside (Ara-C)/idarubicin, her bone marrow showed residual blasts. She was subsequently treated with a second induction regimen of clofarabine and high-dose Ara-C, which resulted in remission of AML, although a residual mast cell infiltrate persisted in her bone marrow. After consolidation therapy with clofarabine/Ara-C, the patient received a stem cell allograft. A follow-up bone marrow showed no residual blasts but persistent mast cells occupying about 5% of the marrow volume.
- Publication
Proceedings (Baylor University. Medical Center), 2014, Vol 27, Issue 1, p22
- ISSN
0899-8280
- Publication type
Case Study
- DOI
10.1080/08998280.2014.11929041