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- Title
The effect of interleukin-16 and its precursor on T lymphocyte activation and growth.
- Authors
Wilson, Kevin C; Center, David M; Cruikshank, William W
- Abstract
Interleukin-16 (IL-16) was the first described T lymphocyte chemoattractant. It has since been shown that IL-16 also functions as a primer of T cell proliferation, a modulator of inflammatory and immune responses, a stimulus of B cell differentiation and an inhibitor of Human immunodeficiency virus (HIV) replication. Its precursor, Prointerleukin-16 (pro-IL-16), is expressed in both the nucleus and cytoplasm of T cells. Cytoplasmic pro-IL-16 serves as the precursor for mature IL-16 while nuclear pro-IL-16 is associated with G0/G1 cell cycle arrest. Herein, we review the ability of IL-16 to act as both primer and modulator of T lymphocyte growth. The impact of IL-16 on T cell apoptosis is also discussed. Finally, we describe the role of pro-IL-16 as a T lymphocyte cell cycle growth suppressor.
- Publication
Growth factors (Chur, Switzerland), 2004, Vol 22, Issue 2, p97
- ISSN
0897-7194
- Publication type
Journal Article
- DOI
10.1080/08977190410001704679