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- Title
Do B cells play a role in the pathogenesis of juvenile idiopathic arthritis?
- Authors
Morbach, H; Girschick, H J
- Abstract
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of diseases. The role of B cells (BC) in autoimmune diseases has been put in a new perspective due to the promising results of BC depleting therapies in RA. Experiments in mouse models have shed new light on the Ab-independent role of BC in the pathogenesis of autoimmune diseases. We discuss whether BC play a role in the pathogenesis of JIA appraising the question for an immunological basis of BC directed therapy.
- Publication
Autoimmunity, 2009, Vol 42, Issue 4, p373
- ISSN
1607-842X
- Publication type
Journal Article
- DOI
10.1080/08916930902832306