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- Title
Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration.
- Authors
Harada, Tatsuhiro; Kyttaris, Vasileios; Li, Yansong; Juang, Yuang-Taung; Wang, Ying; Tsokos, George C
- Abstract
Exposure of T cells to inflammatory cytokines leads to phosphorylation-dependent activation of signal transducer and activator of transcription (STAT) 3. T cells from patients with systemic lupus erythematosus (SLE) display increased levels of total and phosphorylated STAT3 which resides primarily in the nucleus. Increased STAT3 is associated with increased expression of target genes. Silencing of STAT3 expression using a small interfering RNA approach resulted in decreased chemokine-provoked SLE T cell migration. Our data suggest that inhibition of STAT3 expression may reverse the signaling aberrations involved in SLE T cell migration.
- Publication
Autoimmunity, 2007, Vol 40, Issue 1, p1
- ISSN
0891-6934
- Publication type
Journal Article
- DOI
10.1080/08916930601095148