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- Title
Regulation of type 1 diabetes by NKT cells.
- Authors
Novak, Jan; Griseri, Thibault; Beaudoin, Lucie; Lehuen, Agnès
- Abstract
Type 1 diabetes is an autoimmune disease due to the destruction of insulin-producing pancreatic beta cells. Natural Killer T (NKT) cells are a T-cell subset that links the innate and adaptive immune systems. NKT cells play a key regulatory role in type 1 diabetes. The absence of NKT cells correlates with exacerbation of type 1 diabetes, whereas an increased frequency and/or activation of NKT cells prevents beta-cell autoimmunity. Various mechanisms are involved in the protective effect of NKT cells. The goal is now to translate knowledge gained from mouse models into human therapeutics.
- Publication
International reviews of immunology, 2007, Vol 26, Issue 1-2, p49
- ISSN
0883-0185
- Publication type
Journal Article
- DOI
10.1080/08830180601070229