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- Title
Regulatory T cells in immunologic self-tolerance and autoimmune disease.
- Authors
Sakaguchi, Shimon; Sakaguchi, Noriko
- Abstract
Naturally arising CD25+ CD4+ regulatory T cells play key roles in the maintenance of immunologic self-tolerance and negative control of various immune responses. The majority, if not all, of them are produced by the normal thymus as a functionally distinct T-cell subpopulation, and their generation is in part developmentally controlled. Genetic abnormality in the development and function of this population can indeed be a cause of autoimmune disease, immunopathology, and allergy in humans. This regulatory population can be exploited to prevent and treat autoimmune disease by strengthening and reestablishing immunologic self-tolerance.
- Publication
International reviews of immunology, 2005, Vol 24, Issue 3-4, p211
- ISSN
0883-0185
- Publication type
Journal Article
- DOI
10.1080/08830180590934976