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- Title
HLA-class II alleles in Egyptian patients with hepatocellular carcinoma.
- Authors
El-Chennawi, Farha A; Auf, Fatma A; Metwally, Shereen S; Mosaad, Youssef M; El-Wahab, Mohamed A; Tawhid, Ziyad E
- Abstract
Hepatocellular carcinoma (HCC) is linked to environmental, dietary, and life style factors. Its incidence and distribution vary widely among ethnic groups, sex, and geographic regions. HBV and HCV Infection, liver cirrhosis, male gender, and old age are important risk factors of HCC. Variability in outcome following exposure, and the clustering of HCC within families raise the possibility that genetic factors are also involved in susceptibility to HCC. The Major Histocompatibility Complex (MHC) plays a key role in anti-virus and tumor defense. HLA polymorphism is implicated in conferring genetic susceptibility to a large number of immune-mediated diseases, including some cancers. The association between HLA class II antigen and HCC in different ethnic populations that has been reported is controversial. Therefore, the aim of this work was to study the association between HLA class II-DRB1 and DQB1 polymorphism and HCC in Egyptian patients and to investigate their role as risk factors for the development of HCC.
- Publication
Immunological investigations, 2008, Vol 37, Issue 7, p661
- ISSN
1532-4311
- Publication type
Journal Article
- DOI
10.1080/08820130802111605