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- Title
HTR2A: association and expression studies in neuropsychiatric genetics.
- Authors
Norton, Nadine; Owen, Michael J
- Abstract
Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.
- Publication
Annals of medicine, 2005, Vol 37, Issue 2, p121
- ISSN
0785-3890
- Publication type
Journal Article
- DOI
10.1080/07853890510037347