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- Title
DNA pooling as a tool for large-scale association studies in complex traits.
- Authors
Norton, Nadine; Williams, Nigel M; O'Donovan, Michael C; Owen, Michael J
- Abstract
Pooled genotyping is a powerful and efficient tool for high throughput association analysis, both case-control and family-based. The use of pooling designs can significantly reduce the consumable and labour costs of a study. At the same time, since it is also extremely efficient with DNA resources, pooling can be an extremely effective method for conserving DNA. Here, we consider the main points in study design, and illustrate the application of pooling using psychiatric phenotypes as an example.
- Publication
Annals of medicine, 2004, Vol 36, Issue 2, p146
- ISSN
0785-3890
- Publication type
Journal Article
- DOI
10.1080/07853890310021724