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- Title
Cell cycle dysregulation influences survival in high risk breast cancer patients.
- Authors
Königsberg, Robert; Rögelsperger, Olga; Jäger, Walter; Thalhammer, Theresia; Klimpfinger, Martin; De Santis, Maria; Hudec, Marcus; Dittrich, Christian
- Abstract
Cell cycle progression is regulated by cyclin dependent kinases (cdk) and cdk inhibitors. Recent immunohistological studies suggested that dysregulation of cyclin A, cyclin D, cyclin E, p16(ink4), p21(waf1/cip1), and p27(kip1) are of prognostic value in patients with breast cancer. Our study represents the first comprehensive immunohistochemical cell cycle marker analysis for cdc25A, cyclin A, cyclin D, cyclin E, p16(ink4), p21(waf1/cip1), p27(kip1), and pRb in tumor tissue and adjacent benign breast tissue from 69 primarily untreated breast cancer patients.
- Publication
Cancer investigation, 2008, Vol 26, Issue 7, p734
- ISSN
1532-4192
- Publication type
Journal Article
- DOI
10.1080/07357900801944864