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- Title
Enhanced interleukin-10 production by dendritic cells upon stimulation with Toll-like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion.
- Authors
van Lieshout, A W T; Vonk, M C; Bredie, S J H; Joosten, L B A; Netea, M G; van Riel, P L C M; Lafyatis, R; van den Hoogen, F H J; Radstake, T R D J
- Abstract
It has been suggested that the T-cell attracting and profibrotic chemokine CCL18 might play a role in the pathogenesis of systemic sclerosis (SSc). However, it is unclear what underlies the higher CCL18 levels in SSc. The aim of our study was to determine whether Toll-like receptor (TLR)-mediated stimulation of monocytes and dendritic cells (DCs) contributes to the higher levels of CCL18 in SSc.
- Publication
Scandinavian journal of rheumatology, 2009, Vol 38, Issue 4, p282
- ISSN
1502-7732
- Publication type
Journal Article
- DOI
10.1080/03009740802572467