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- Title
Effects of alginate hydrogels and TGF-beta 1 on human dental pulp repair in vitro.
- Authors
Dobie, K; Smith, G; Sloan, A J; Smith, A J
- Abstract
The objective of this study was to investigate the use of alginate hydrogels to present either exogenous or endogenous transforming growth factor (TGF)-beta 1 to the dentin-pulp complex to signal reparative processes. Hydrogels were prepared, applied to cultured human tooth slices and the effects on tertiary dentinogenesis examined histologically. Both TGF-beta 1-containing and acid-treated alginate hydrogels, but not untreated hydrogels, upregulated dentin matrix secretion and induced odontoblast-like cell differentiation with subsequent secretion of regular tubular dentin matrix on cut pulpal surfaces. It is concluded that TGF-beta 1 can signal both induction of odontoblast-like cell differentiation and upregulation of their matrix secretion in the human dentin-pulp complex. Alginate hydrogels provide an appropriate matrix in which dental regeneration can take place and may also be useful for delivery of growth factors, including TGF-beta s, to enhance the natural regenerative capacity of the dental pulp.
- Publication
Connective tissue research, 2002, Vol 43, Issue 2-3, p387
- ISSN
0300-8207
- Publication type
Journal Article
- DOI
10.1080/03008200290000574