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- Title
Co-expression of estrogen receptor alpha and Apolipoprotein D in node positive operable breast cancer--possible relevance for survival and effects of adjuvant tamoxifen in postmenopausal patients.
- Authors
Søiland, Håvard; Skaland, Ivar; Varhaug, Jan Erik; Kørner, Hartwig; Janssen, Emiel A M; Gudlaugsson, Einar; Baak, Jan P A; Søreide, Jon Arne
- Abstract
Estrogen receptor-alpha (ERalpha) is an important prognostic and predictive marker in breast cancer. ERalpha signaling normally down-regulates expression of Apolipoprotein D (ApoD), a lipocalin that binds, transports or chelates lipophilic ligands, including tamoxifen (TAM). Hence, the co-expression of ApoD may therefore identify clinical relevant subgroups of ERalpha positive breast cancer patients.
- Publication
Acta oncologica (Stockholm, Sweden), 2009, Vol 48, Issue 4, p514
- ISSN
1651-226X
- Publication type
Journal Article
- DOI
10.1080/02841860802620613