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- Title
Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?
- Authors
Hedman, Håkan; Nilsson, Jonas; Guo, Dongsheng; Henriksson, Roger
- Abstract
The LRIG1 gene (formerly LIG-1), recently cloned by us, displays structural similarities to the Drosophila Kek I gene. Kek I encodes a cell surface protein, Kekkon-1, which inhibits epidermal growth factor receptor-mediated signalling. We localized the LRIG1 gene to chromosome band 3p14.3, a region known to be deleted in various human cancers. In the present study LRIG1 gene expression was examined in different tumour cell lines and corresponding normal tissues by real-time RT-PCR. In many tumour cell lines, LRIG1 expression appeared absent or was down regulated compared to corresponding normal tissues. The results are consistent with LRIG1 being a tumour suppressor gene in humans. However, further studies are justified to elucidate the explicit role of LRIG1 as a negative regulator of oncogenesis.
- Publication
Acta oncologica (Stockholm, Sweden), 2002, Vol 41, Issue 4, p352
- ISSN
0284-186X
- Publication type
Journal Article
- DOI
10.1080/028418602760169398