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- Title
Single dose of 24 milligrams of buprenorphine for heroin detoxification: an open-label study of five inpatients.
- Authors
Ang-Lee, Kathleen; Oreskovich, Michael R; Saxon, Andrew J; Jaffe, Craig; Meredith, Charles; Ellis, Mei Ling K; Malte, Carol A; Knox, Patricia C
- Abstract
Previous studies indicate that buprenorphine has efficacy in medically supervised opioid withdrawal, but the optimal dosing for maximum tolerability and ease of administration remains undetermined. Five heroin-dependent individuals entered this open-label study of inpatient detoxification with a single 24 mg dose of buprenorphine. The mean Clinical Opiate Withdrawal Scale (COWS) score prior to buprenorphine administration was 17.6 (SD = 3.36). COWS scores declined significantly thereafter. There was one episode of precipitated withdrawal that resolved within four hours. Use of ancillary medications was minimal. This study suggests that a single high dose of buprenorphine can be used safely and effectively for inpatient detoxification.
- Publication
Journal of psychoactive drugs, 2006, Vol 38, Issue 4, p505
- ISSN
0279-1072
- Publication type
Journal Article
- DOI
10.1080/02791072.2006.10400589