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- Title
Activation of TGF-beta1 through up-regulation of TSP-1 by retinoic acid in retinal pigment epithelial cells.
- Authors
Uchida, Hiroko; Kuroki, Motomu; Shitama, Tomomi; Hayashi, Hideyuki; Kuroki, Masahide
- Abstract
Retinoic acid (RA) affects the activation of transforming growth factor-beta 1 (TGF-beta1) in a variety of cells. We have previously shown that thrombospondin-1 (TSP-1) expression in retinal pigment epithelial (RPE) cells is up-regulated by RA. Since TSP-1 activates TGF-beta1, we investigated whether RA stimulates the activation of TGF-beta1 through up-regulation of TSP-1 in RPE cells.
- Publication
Current eye research, 2008, Vol 33, Issue 2, p199
- ISSN
0271-3683
- Publication type
Journal Article
- DOI
10.1080/02713680701852090