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- Title
Structure elucidation of sildenafil analogues in herbal products.
- Authors
Blok-Tip, L; Zomer, B; Bakker, F; Hartog, K D; Hamzink, M; Ten Hove, J; Vredenbregt, M; De Kaste, D
- Abstract
The structure of unknown compounds present in herbal products was elucidated using liquid chromatography-electrospray ionization-mass spectrometry, direct-infusion electrospray ionization-mass spectrometry, and nuclear magnetic resonance. Compounds 1-3 were identified as sildenafil analogues, 1 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine, and an acetyl group instead of the sulfonyl group, named acetildenafil, 2 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine (homosildenafil), and 3 bearing an N-hydroxylethylpiperazine moiety instead of an N-methylpiperazine, named hydroxyhomosildenafil. When analysing products marketed for penile erectile dysfunction or marketed as aphrodisiacs, attention should be given to the possible presence of these components.
- Publication
Food additives and contaminants, 2004, Vol 21, Issue 8, p737
- ISSN
0265-203X
- Publication type
Journal Article
- DOI
10.1080/02652030412331272467