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- Title
Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology?
- Authors
Plopper, Charles G; Smiley-Jewell, Suzette M; Miller, Lisa A; Fanucchi, Michelle V; Evans, Michael J; Buckpitt, Alan R; Avdalovic, Mark; Gershwin, Laurel J; Joad, Jesse P; Kajekar, Radhika; Larson, Shawnessy; Pinkerton, Kent E; Van Winkle, Laura S; Schelegle, Edward S; Pieczarka, Emily M; Wu, Reen; Hyde, Dalla M
- Abstract
The recent, dramatic increase in the incidence of childhood asthma suggests a role for environmental contaminants in the promotion of interactions between allergens and the respiratory system of young children. To establish whether exposure to an environmental stressor, ozone (O3), and an allergen, house dust mite (HDMA), during early childhood promotes remodeling of the epithelial-mesenchymal trophic unit (EMTU) of the tracheobronchial airway wall by altering postnatal development, infant rhesus monkeys were exposed to cyclic episodes of filtered air (FA), HDMA, O3, or HDMA plus O3. The following alterations in the EMTU were found after exposure to HDMA, O3, or HDMA plus O3: (1) reduced airway number; (2) hyperplasia of bronchial epithelium; (3) increased mucous cells; (4) shifts in distal airway smooth muscle bundle orientation and abundance to favor hyperreactivity; (5) interrupted postnatal basement membrane zone differentiation; (6) modified epithelial nerve fiber distribution; and (7) reorganization of the airway vascular and immune system.
- Publication
Toxicologic pathology, 2007, Vol 35, Issue 1, p97
- ISSN
0192-6233
- Publication type
Journal Article
- DOI
10.1080/01926230601132030