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- Title
Genotyping of CYP2B6 and therapeutic drug monitoring in an HIV-infected patient with high efavirenz plasma concentrations and severe CNS side-effects.
- Authors
Mathiesen, Sofie; Justesen, Ulrik Stenz; Von Lüttichau, Hans-Rudolf; Hansen, Ann-Brit Eg
- Abstract
We present a case with important pharmacogenetic and pharmacokinetic aspects of antiretroviral therapy in a patient with high efavirenz concentrations, severe CNS side-effects and low lopinavir concentrations. Despite therapeutic drug monitoring and subsequent efavirenz dosage reductions, side-effects did not resolve completely and lopinavir concentrations remained relatively low.
- Publication
Scandinavian journal of infectious diseases, 2006, Vol 38, Issue 8, p733
- ISSN
0036-5548
- Publication type
Journal Article
- DOI
10.1080/00365540500504109