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- Title
Tubulopathy consecutive to tenofovir-containing antiretroviral therapy in two patients infected with human immunodeficiency virus-1.
- Authors
Breton, Guillaume; Alexandre, Marina; Duval, Xavier; Prie, Dominique; Peytavin, Gilles; Leport, Catherine; Vildei, Jean-Louis
- Abstract
Tenofovir disopril fumarate, a new nucleotide analogue against human immunodeficiency virus-1 (HIV-1), can induce hypophosphataemia, the mechanism of which is unclear. Moreover, a renal tubulopathy can occur in long-term treated patients, as observed in 2 HIV-1-infected patients after 12 months of tenofovir therapy, with polyuria-polydipsia, proteinuria, glycosuria and amino-aciduria, which resolved after discontinuation of tenofovir. The risk of renal tubulopathy symptoms in patients on long-term tenofovir therapy should be noted.
- Publication
Scandinavian journal of infectious diseases, 2004, Vol 36, Issue 6-7, p527
- ISSN
0036-5548
- Publication type
Journal Article
- DOI
10.1080/00365540310016169