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- Title
Helicobacter pylori infection in interleukin-4-deficient and transgenic mice.
- Authors
Chen, W; Shu, D; Chadwick, V S
- Abstract
Interleukin (IL)-4 is a potent anti-inflammatory and Th2-type immunoregulatory cytokine. Helicobacter pylori infection in humans induces a polarized Th1 immune response characterized by increased production of interferon-gamma and absence of IL-4. This study was designed to determine the role of endogenous IL-4 in the host defence against gastric colonization by H. pylori using IL-4-deficient (IL-4-/-) and transgenic (IL-4 Tg) mice.
- Publication
Scandinavian journal of gastroenterology, 1999, Vol 34, Issue 10, p987
- ISSN
0036-5521
- Publication type
Journal Article
- DOI
10.1080/003655299750025084