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- Title
Interleukin 1-beta gene polymorphisms and risk of gastric cancer in Sweden.
- Authors
Persson, Christina; Engstrand, Lars; Nyrén, Olof; Hansson, Lars-Erik; Enroth, Helena; Ekström, Anna-Mia; Ye, Weimin
- Abstract
Helicobacter pylori (H. pylori) infection stimulates the production of interleukin (IL)-1 beta, a pro-inflammatory cytokine and suppressor of gastric acid secretion. As both inflammation and hypochlorhydria, which might facilitate proximal colonization of H. pylori and other bacterial species alike, have been implicated in gastric carcinogenesis, much attention has been directed to functional genetic polymorphisms that affect the production of IL-1 beta. The purpose of this study was to clarify the role of these polymorphisms.
- Publication
Scandinavian journal of gastroenterology, 2009, Vol 44, Issue 3, p339
- ISSN
1502-7708
- Publication type
Journal Article
- DOI
10.1080/00365520802556015