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- Title
Serum gastrin and chromogranin A levels in patients with fundic gland polyps caused by long-term proton-pump inhibition.
- Authors
Fossmark, Reidar; Jianu, Constantin S; Martinsen, Tom C; Qvigstad, Gunnar; Syversen, Unni; Waldum, Helge L
- Abstract
Use of proton-pump inhibitors (PPIs) causes hypergastrinemia, and it is well known that gastrin has a trophic effect on the oxyntic mucosa. Some PPI users develop fundic gland polyps. The purpose of this study was to determine whether patients developing fundic gland polyps have a more pronounced gastric hypoacidity, hypergastrinemia or increased serum chromogranin A (CgA), which is an enterochromaffin-like (ECL) cell marker.
- Publication
Scandinavian journal of gastroenterology, 2008, Vol 43, Issue 1, p20
- ISSN
0036-5521
- Publication type
Journal Article
- DOI
10.1080/00365520701561959