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- Title
Interleukin-4 gene transfer into rat pancreas by recombinant adenovirus.
- Authors
Brock, Peter; Sparmann, Gisela; Ritter, Thomas; Jaster, Robert; Liebe, Stefan; Emmrich, Jörg
- Abstract
Adenovirus-mediated gene transfer technology may provide a novel approach in the treatment of pancreatic diseases. In the rat model of chronic pancreatitis induced by dibutyltin dichloride (DBTC), Th1 lymphocytes are known to be involved in the mediation of inflammation. We therefore investigated whether local expression of the Th2 cytokine interleukin (IL)-4 might modulate the inflammatory response. To address this question, we have established a protocol of efficient gene transfer into rat pancreas.
- Publication
Scandinavian journal of gastroenterology, 2005, Vol 40, Issue 9, p1109
- ISSN
0036-5521
- Publication type
Journal Article
- DOI
10.1080/00365520510023404