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- Title
Feasibility study of using fetal DNA in maternal plasma for non-invasive prenatal diagnosis.
- Authors
Liu, Fu-Min; Wang, Xiu-Ying; Feng, Xia; Wang, Wen; Ye, Yue-Xian; Chen, Hong
- Abstract
The discovery of the presence of fetal genetic material in maternal blood has opened up a new approach to prenatal diagnosis. One approach that has been extensively investigated over the past few decades is the isolation of fetal cells from maternal blood (Herzenberg et al. Proc Natl Acad Sci USA. 1979;76:1453-5; Bianchi et al. Proc Natl Acad Sci USA. 1990;87:3279-83; Cha et al. Prenat Diagn. 2005;25:586-91). As the fetal cells are scarce and the enrichment is of low efficiency, the technique could not be implemented in clinics. In 1997, Lo et al. (Lancet 1997;350(9076):485-7) discovered that cell-free fetal DNA is present in the plasma and serum of pregnant women. This discovery suggests that maternal plasma/serum DNA may be a useful source of material for non-invasive prenatal diagnosis. The objective of our study was to investigate the feasibility of using fetal DNA in maternal plasma for prenatal diagnosis.
- Publication
Acta obstetricia et gynecologica Scandinavica, 2007, Vol 86, Issue 5, p535
- ISSN
0001-6349
- Publication type
Journal Article
- DOI
10.1080/00016340601159124