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- Title
Photodynamic Therapy by Topical Aminolevulinic Acid, Dimethylsulphoxide and Curettage in Nodular Basal Cell Carcinoma: a One-year Follow-up Study.
- Authors
Maria Soler, Ana; Warloe, Trond; Tausjø, Johan; Berner, Aasmund
- Abstract
Fifty-eight patients with 119 nodular (2 mm or more in thickness) basal cell carcinomas successfully treated with photodynamic therapy were included in this 1-year follow-up study. The initial cure rate at 3-6 months was 92% after photodynamic therapy, which included an initial debulking procedure and topical application of dimethylsulphoxide in order to enhance penetration of 5-aminolevulinic acid (20% in cream) to which the lesions were exposed for 3 h prior to exposure to light. At examination 12-26 months (mean 17 months) after treatment 113 lesions (95%) were still in complete response. Six lesions (5%) had recurred, located on the face, scalp and ear. The cosmetic outcome was evaluated as excellent to good in 91%. Microscopic examination of biopsies taken from healed areas in 7 patients did not reveal any sign of damage in 5 and only minor alterations in 2.
- Publication
Acta Dermato-Venereologica, 1999, Vol 79, Issue 3, p204
- ISSN
0001-5555
- Publication type
Academic Journal
- DOI
10.1080/000155599750010977