Title

Alpha Helix Nucleation by a Simple Cyclic Tetrapeptide.

Authors

Hoang, Huy N.; Chongyang Wu; Beyer, Renee L.; Hill, Timothy A.; Fairlie, David P.

Abstract

The simple cyclic tetrapeptide cyclo-(1,4)-[Ala-Arg-Ala-homoGlu]-NH2 (3) is shown to adopt an unusual α-turn structure, which is not α-helical but can nucleate α-helicity when attached to the N-terminus of either model peptides or two biologically relevant peptides. This new N-terminal helix-capping macrocycle provides very simple and rapid synthetic access to α-helical peptide structures.

Subjects

CYCLIC peptides; NUCLEATION; CHEMICAL structure

Publication

Australian Journal of Chemistry, 2017, Vol 70, Issue 2, p213

ISSN

0004-9425

Publication type

Academic Journal

DOI

10.1071/CH16591