We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Large-scale simulations of fluctuating biological membranes.
- Authors
Pasqua, Andrea; Maibaum, Lutz; Oster, George; Fletcher, Daniel A; Geissler, Phillip L
- Abstract
We present a simple, and physically motivated, coarse-grained model of a lipid bilayer, suited for micron scale computer simulations. Each approximately 25 nm(2) patch of bilayer is represented by a spherical particle. Mimicking forces of hydrophobic association, multiparticle interactions suppress the exposure of each sphere's equator to its implicit solvent surroundings. The requirement of high equatorial density stabilizes two-dimensional structures without necessitating crystalline order, allowing us to match both the elasticity and fluidity of natural lipid membranes. We illustrate the model's versatility and realism by characterizing a membrane's response to a prodding nanorod.
- Publication
The Journal of chemical physics, 2010, Vol 132, Issue 15, p154107
- ISSN
1089-7690
- Publication type
Journal Article
- DOI
10.1063/1.3382349