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- Title
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.
- Authors
Scott, Linda M; Tong, Wei; Levine, Ross L; Scott, Mike A; Beer, Philip A; Stratton, Michael R; Futreal, P Andrew; Erber, Wendy N; McMullin, Mary Frances; Harrison, Claire N; Warren, Alan J; Gilliland, D Gary; Lodish, Harvey F; Green, Anthony R
- Abstract
The V617F mutation, which causes the substitution of phenylalanine for valine at position 617 of the Janus kinase (JAK) 2 gene (JAK2), is often present in patients with polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis. However, the molecular basis of these myeloproliferative disorders in patients without the V617F mutation is unclear.
- Publication
The New England journal of medicine, 2007, Vol 356, Issue 5, p459
- ISSN
1533-4406
- Publication type
Journal Article
- DOI
10.1056/NEJMoa065202