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- Title
Effect of platelet-rich plasma on bone regeneration in autogenous bone graft.
- Authors
Choi, B-H; Im, C-J; Huh, J-Y; Suh, J-J; Lee, S-H
- Abstract
In this study, we evaluated the effect of platelet-rich plasma (PRP) on bone regeneration in an autogenous bone graft in a canine model. The mandibular premolar teeth had been bilaterally extracted previously, and the ridges had been allowed to heal for 3 months. After this period, continuity resection was performed on both sides of the mandible. One defect (the PRP group) was reconstructed with the original particulate bone mixed with PRP. As a control, the contralateral defect (non-PRP group) was reconstructed with the original particulate bone alone. Biopsies after 6 weeks showed lower levels of bone formation in the PRP group than in the non-PRP group, and fluorescence microscopy revealed a delay in the remodelling of grafts loaded with PRP. These findings suggest that the addition of PRP does not appear to enhance new bone formation in autogenous bone grafts.
- Publication
International journal of oral and maxillofacial surgery, 2004, Vol 33, Issue 1, p56
- ISSN
0901-5027
- Publication type
Journal Article
- DOI
10.1054/ijom.2003.0466