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- Title
Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer.
- Authors
Leung, W K; To, K F; Ng, Y P; Lee, T L; Lau, J Y; Chan, F K; Ng, E K; Chung, S C; Sung, J J
- Abstract
Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer.
- Publication
British journal of cancer, 2001, Vol 84, Issue 3, p335
- ISSN
0007-0920
- Publication type
Journal Article
- DOI
10.1054/bjoc.2000.1607