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- Title
A non-invasive selective assessment of type I fibre mitochondrial function using 31P NMR spectroscopy. Evidence for impaired oxidative phosphorylation rate in skeletal muscle in patients with chronic heart failure.
- Authors
van der Ent, M; Jeneson, J A; Remme, W J; Berger, R; Ciampricotti, R; Visser, F
- Abstract
Skeletal muscle abnormalities contribute considerably to the clinical expression of heart failure. Deconditioning, underperfusion and an increased number of type IIb glycolytical fibres lead to early lactate production and muscle fatigue at low exercise levels. Aerobic muscle metabolism may also be impaired, as suggested by biopsy studies. Thus far, no data are available from non-invasive studies to indicate the extent of aerobic muscle dysfunction during low-grade exercise which does not induce acidosis.
- Publication
European heart journal, 1998, Vol 19, Issue 1, p124
- ISSN
0195-668X
- Publication type
Journal Article
- DOI
10.1053/euhj.1997.0727