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- Title
Use of recombinant human antithrombin in patients with congenital antithrombin deficiency undergoing surgical procedures.
- Authors
Konkle, Barbara A; Bauer, Kenneth A; Weinstein, Robert; Greist, Anne; Holmes, Houston E; Bonfiglio, Judith
- Abstract
Hereditary antithrombin (AT) deficiency is associated with a significant risk of venous thromboembolism. Patients with this disorder frequently require long-term anticoagulation. Discontinuation of anticoagulation for childbirth or surgery may carry a substantial thrombotic risk. For this reason, replacement with AT concentrate has been used when anticoagulation is interrupted. A new recombinant human AT concentrate, produced using transgenic technology, has recently been developed.
- Publication
Transfusion, 2003, Vol 43, Issue 3, p390
- ISSN
0041-1132
- Publication type
Journal Article
- DOI
10.1046/j.1537-2995.2003.00315.x