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- Title
Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina.
- Authors
Sills, Graeme J; Butler, Elaine; Forrest, Gerard; Ratnaraj, Neville; Patsalos, Philip N; Brodie, Martin J
- Abstract
The antiepileptic drug (AED) vigabatrin (VGB), which exerts its pharmacologic effects on the gamma-aminobutyric acid (GABA) system, causes concentric visual field constriction in >40% of exposed adults. This may be a class effect of all agents with GABA-related mechanisms of action. We compared the concentration-related effects of VGB in rat brain and eye with those of gabapentin (GBP) and topiramate (TPM), both of which have been reported to elevate brain GABA concentrations in humans.
- Publication
Epilepsia, 2003, Vol 44, Issue 7, p886
- ISSN
0013-9580
- Publication type
Journal Article
- DOI
10.1046/j.1528-1157.2003.04203.x