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- Title
Glutamate-glutamine cycling in the epileptic human hippocampus.
- Authors
Petroff, Ognen A C; Errante, Laura D; Rothman, Douglas L; Kim, Jung H; Spencer, Dennis D
- Abstract
Several findings suggest that energy metabolism and the glutamate-glutamine cycle may be impaired in epilepsy. Positron emission tomography often shows interictal hypometabolism of the epileptogenic hippocampus. In vivo microdialysis studies show that seizure-associated glutamate release is doubled, and clearance is slowed. We hypothesized that the glutamate-glutamine cycle between neurons and glia may be decreased in the epileptic human hippocampus.
- Publication
Epilepsia, 2002, Vol 43, Issue 7, p703
- ISSN
0013-9580
- Publication type
Journal Article
- DOI
10.1046/j.1528-1157.2002.38901.x