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- Title
Homocysteine enhances TIMP-1 expression and cell proliferation associated with NADH oxidase in rat mesangial cells.
- Authors
Yang, Zhi-Zhang; Zou, Ai-Ping
- Abstract
Recent studies in our laboratory demonstrated that chronic hyperhomocysteinemia (hHcys) induced glomerular sclerosis. The mechanism mediating hHcys-induced glomerular damage remains unknown. The present study was designed to test a hypothesis that homocysteine (Hcys) increases the production by nicotinamide adenine dinucleotide (NADH) oxidase and thereby stimulates the formation of tissue inhibitor of metalloproteinase (TIMP-1) in rat mesangial cells, consequently leads to glomerulosclerosis.
- Publication
Kidney international, 2003, Vol 63, Issue 3, p1012
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2003.00825.x