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- Title
Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease.
- Authors
Nagao, Shizuko; Yamaguchi, Tamio; Kusaka, Masatomo; Maser, Robin L; Takahashi, Hisahide; Cowley, Benjamin D; Grantham, Jared J
- Abstract
Abnormal proliferation of renal tubule epithelial cells is a central factor in the biogenesis and sustained expansion of cysts in autosomal-dominant polycystic kidney disease (ADPKD). Recent evidence from in vitro studies of human cyst wall epithelial cells has implicated a role for the mitogen-activated protein (MAP) kinase pathway in this aberrant proliferation. To determine the extent to which this signaling pathway is involved in cyst pathogenesis in vivo, we measured the expression of select components of the MAP kinase cascade in Han:SPRD rats with ADPKD at an early stage of the disease.
- Publication
Kidney international, 2003, Vol 63, Issue 2, p427
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2003.00755.x