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- Title
Dose-dependent effects of strontium on osteoblast function and mineralization.
- Authors
Verberckmoes, Steven C; De Broe, Marc E; D'Haese, Patrick C
- Abstract
Strontium-ranelate is now being used in the treatment of osteoporosis in elderly patients. As the majority of these patients already have a decreased renal function they are at an increased risk for accumulation of the element. Recent findings from epidemiologic studies in dialysis patients and experimental data obtained in a chronic renal failure (CRF) rat model established a dose-related multiphasic effect of strontium (Sr) on bone formation. To confirm these in vivo findings an in vitro set-up, consisting of primary rat osteoblast cultures, was applied. Sr was added to the culture medium at concentrations of 0, 0.5, 1.0, 2.0, 5.0, 20, and 100 microg/mL, respectively.
- Publication
Kidney international, 2003, Vol 64, Issue 2, p534
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2003.00123.x