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- Title
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys.
- Authors
Yamaguchi, Tamio; Nagao, Shizuko; Wallace, Darren P; Belibi, Franck A; Cowley, Benjamin D; Pelling, Jill C; Grantham, Jared J
- Abstract
The proliferation of mural epithelial cells is a major cause of progressive cyst enlargement in autosomal-dominant polycystic kidney disease (ADPKD). Adenosine 3', 5' cyclic monophosphate (cAMP) stimulates the proliferation of cells from ADPKD cysts, but not cells from normal human kidney cortex (HKC), through the activation of protein kinase A (PKA), mitogen-activated protein kinase kinase (MEK), and extracellular signal-regulated kinase (ERK/MAPK). In the current study, we examined the signaling pathway between PKA and MEK in ADPKD and HKC cells.
- Publication
Kidney international, 2003, Vol 63, Issue 6, p1983
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2003.00023.x