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Title
Glucocorticoids interfere with mycophenolate mofetil bioavailability in kidney transplantation.
Authors
Cattaneo, Dario; Perico, Norberto; Gaspari, Flavio; Gotti, Eliana; Remuzzi, Giuseppe
Abstract
Steroids have been shown to induce the hepatic glucuronyltransferase (GT) expression enhancing the activity of uridine diphosphate-GT, the enzyme responsible for mycophenolic acid (MPA) metabolism. The impact of steroids on MPA pharmacokinetics, however, has not been investigated to date.