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- Title
Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury.
- Authors
Han, Won K; Bailly, Veronique; Abichandani, Rekha; Thadhani, Ravi; Bonventre, Joseph V
- Abstract
Traditional blood and urine markers for the diagnosis of various renal diseases are insensitive and nonspecific. Kidney Injury Molecule-1 (KIM-1) is a type 1 transmembrane protein, with an immunoglobulin and mucin domain, whose expression is markedly up-regulated in the proximal tubule in the post-ischemic rat kidney. The ectodomain of KIM-1 is shed from cells. The current studies were carried out to evaluate whether KIM-1 is present in human acute renal failure and might serve as a urinary marker of acute renal tubular injury.
- Publication
Kidney international, 2002, Vol 62, Issue 1, p237
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2002.00433.x