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- Title
Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification.
- Authors
Kaunisto, Kari; Parkkila, Seppo; Rajaniemi, Hannu; Waheed, Abdul; Grubb, Jeffrey; Sly, William S
- Abstract
Carbonic anhydrase (CA) plays a fundamental role in regulation of systemic acid-base homeostasis by facilitating urinary acidification. Four CA isozymes (CA II, IV, XII, XIV) have been identified in kidney. Until now, luminal CA IV, a GPI-anchored isozyme, was thought to mediate most bicarbonate absorption. Although CA XIV mRNA has been demonstrated in mouse and human kidney, the localization of this newly discovered CA has not been established.
- Publication
Kidney international, 2002, Vol 61, Issue 6, p2111
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2002.00371.x